At the completion of this activity, the participant will be able to:

Explain core antimicrobial PK/PD concepts (volume of distribution, clearance, protein binding, and exposure targets) relevant to dose individualization
Identify physiologic changes in hypoalbuminemia, obesity, low body weight, and pregnancy that may change antibiotic exposure
Recognize how ARC, RRT/CRRT, and ECMO influence drug elimination, distribution, or circuit-related drug loss
State the different circumstances in which customary dosing is likely to result in underexposure of potentially excessive exposure
Identify patient-specific information, organism susceptibility, and available drug-level monitoring to select of reassess a dosing strategy